Bioinformatics Practice Test 9

1. Which of the following is wrong about European Molecular Biology Laboratory Data Library Format?

EMBL maintains DNA and protein sequence databases

As with GenBank entries, a large amount of information describing each sequence entry is given

Information is organized into fields, each with an identifier, shown as the first text on each line

Sequence entry includes literature references and information about the function of the sequence, but not locations of mRNAs and coding regions

2. The linkers between the catalytic domain and the Rossmann domain were conserved in each family.

True

False

3. In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.

True

False

4. Which of the following is incorrect about Retrieving a Specific Sequence?

It can be difficult to retrieve the sequence of a specific gene or protein simply because of the sheer number of sequences in the Gen-Bank database and the complex problem of indexing them

Other projects may benefit from the availability of better curated and annotated protein sequence databases, but not PIR and SwissProt

The genomic databases can also provide the sequence of a particular gene or protein. Protein sequences in the Genpro database are generated by automatic translation of DNA sequences

For projects that require the most currently available sequences, the NR databases should be searched

5. In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.

True

False

6. The FASTA format is readily converted into other formats and also is smaller and simpler.

True

False

7. An alternative method is to sequence all the subclones, produce a computer database of the sequences, and then have the computer assemble the sequences from the overlaps that are found.

False

True

8. Many levels of clone redundancy may be required to build a consensus map because individual clones can have _______

deletions

two separate fragments

rearrangements

vectors

9. The chromosomes comprised linear DNA molecules in a tightly compact form that was wrapped around protein complexes, called the nucleosome.

True

False

10. The sequence can also be verified by making an oligonucleotide primer complementary to the distal part of the readable sequence and using it to obtain the sequence of the complementary strand on the original DNA template.

False

True