Bioinformatics Mock Test 10

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Question 1 of 10

1. _______ of the Drosophila sequence is composed of TEs and _____ is heterochromatic regions that do not include genes.

one-fourth, one-third

one-fifth, one-fourth

one-sixth, one-eighth

one-sixth, one-third

Question 1 of 10

Question 2 of 10

2. Each genome sequence is scanned for protein-encoding genes using gene models trained on known gene sequences from the same organism.

True

False

Question 2 of 10

Question 3 of 10

3. Minisatellites are made up of repeat units of up to ____ and microsatellites compose of repeat units of ____ or less.

80 bp, 9 bp

70 bp, 6 bp

25 bp, 4 bp

25 bp, 10 bp

Question 3 of 10

Question 4 of 10

4. Introns can remain at a corresponding position in a eukaryotic gene for long periods of evolutionary time.

True

False

Question 4 of 10

Question 5 of 10

5. Which of the given statement is incorrect?

Each protein of one proteome is selected in turn as a query of the proteome of another single organism only

Each protein of one proteome is selected in turn as a query of the proteome of another organism or the combined proteome of a group of organisms

As in an all-by-all protein comparison within a proteome, a matrix of alignment scores with E values is made, and the most closely related sequences in the two organisms are identified

To perform a between-proteome analysis, proteome databases are made for the known and predicted genes of two or more genomes

Question 5 of 10

Question 6 of 10

6. In protein/domain analysis, each protein in the predicted proteome is again used as a query of a curated protein sequence database such as ____ in order to locate similar domains and sequences. To find orthologs, very low E value scores (E<10<20) for the alignment score and an alignment that includes 60–80% of the query sequence are generally required in order to avoid matches to paralogs.

SwissProt

Genbank

PubChem

MeSH

Question 6 of 10

Question 7 of 10

7. Comparative genomics includes a comparison of gene number, gene content, and gene location in both prokaryotic and eukaryotic groups of organisms.

False

True

Question 7 of 10

Question 8 of 10

8. Which of the given statement is incorrect about Orthologs?

The best hit in each proteome is likely to be with an ortholog of the query gene

To identify orthologs, each protein in the proteome of an organism is used as a query in a similarity search of a database comprising the proteomes of only one different organism

In comparing two proteomes, a common standard is to require that for each pair of orthologs, the first of the pair is the best hit when the second is used to query the proteome of the first

Orthologs are genes that are so highly conserved by sequence in different genomes that the proteins they encode are strongly predicted to have the same structure and function and to have arisen from a common ancestor through speciation

Question 8 of 10

Question 9 of 10

9. SVMs (Support vector machines) are a binary classification method to discriminate one set of data points from another.

True

False

Question 9 of 10

Question 10 of 10

10. Eukaryotic genes that encode proteins are interrupted by ________

exons of varying length and but same number

introns of varying number but same length

exons of varying length and number

introns of varying length and number

Question 10 of 10