Bioinformatics Mock Test 4

10%

Question 1 of 10

1. In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.

True

False

Question 1 of 10

Question 2 of 10

2. Which of the following is untrue about threading and fold recognition?

It assess the compatibility of an amino acid sequence with a known structure in a fold library

Threading and fold recognition do not generate fully refined atomic models for the query sequences

If the protein fold to be predicted does not exist in the fold library, the method will fail

If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail

Question 2 of 10

Question 3 of 10

3. Which of the following is untrue regarding Coils?

It compares the sequence to a probability matrix compiled from known parallel two-stranded coiled coils

It is a web-based program that detects coiled coil regions in proteins

It scans a window of fourteen, twenty-one, or twenty-eight residues

It scans a window of fourteen or twenty-one residues only

Question 3 of 10

Question 4 of 10

4. Which of the following is not a base of RNA?

Thymine (T)

Cytosine (C)

Adenine (A)

Guanine (G)

Question 4 of 10

Question 5 of 10

5. In CATH, Structural domain separation is carried by ___________

manual comparison only

computer programs only

a combined effort of a human expert and computer programs

human expertise only

Question 5 of 10

Question 6 of 10

6. The last step in structure classification involves grouping proteins/domains of similar structures.

True

False

Question 6 of 10

Question 7 of 10

7. Which of the following is true regarding Prediction of β-Barrel Membrane Proteins?

For membrane proteins with β-strands only, the β-strands forming the transmembrane segment are amphipathic in nature

For membrane proteins with β-strands only, the β-strands forming the transmembrane segment are only hydrophilic in nature

For membrane proteins with β-strands only, the β-strands forming the transmembrane segment are only hydrophobic in nature

They contain six to nine residues

Question 7 of 10

Question 8 of 10

8. The scoring scheme based on the combined stabilizing and destabilizing interactions forms the foundation of the ab initio RNA secondary structure prediction method.

False

True

Question 8 of 10

Question 9 of 10

9. Which of the following is incorrect about Multiple Structure Alignment?

The alignment strategy is different than the Clustal sequence alignment using a progressive approach

All structures are first compared in a pairwise fashion

A distance matrix is developed based on structure similarity scores such as RMSD

The aligned structures create a median structure that allows other structures to be progressively added for comparison based on the hierarchy described in the guide tree

Question 9 of 10

Question 10 of 10

10. In addition to the canonical base pairing, there often exists non-canonical base pairing such as _________ and ________ base paring.

G, U

U, C

G, C

A, C

Question 10 of 10