Bioinformatics Mock Test 8

10%

Question 1 of 10

1. Which of the following is untrue about Amino acid conservation?

Conservation of residues at the core of a protein family is often related to function

This may be an enzyme active-site or binding site

Unlike hydrophobicity or electrostatic potential, displaying residue conservation on the molecular surface has no physical or chemical basis

It has been known for some time that conservation of residues at the surface of a protein family is often related to function

Question 1 of 10

Question 2 of 10

2. rVISTA uses two orthologous sequences as input and first identifies all putative regulatory motifs based on TRANSFAC matches.

False

True

Question 2 of 10

Question 3 of 10

3. In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.

low-energy conformations, after

high-energy conformations, after

low-energy conformations, prior to

high-energy conformations, prior to

Question 3 of 10

Question 4 of 10

4. The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.

N/2

N²

N +1

Question 4 of 10

Question 5 of 10

5. Which of the following is incorrect regarding Eponine?

It is a web-based program that predicts transcription start sites

It is based on a series of pre-constructed PSSMs of several regulatory sites

It is a web-based program that particularly predicts tranpososons and retropososons

The regulatory sites include the TATA box, the CCAAT box, and CpG islands

Question 5 of 10

Question 6 of 10

6. In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.

large molecule, highly flexible

large molecule, more flexible

small molecule, highly flexible

small molecule, less flexible

Question 6 of 10

Question 7 of 10

7. The use of Markov models in gene finding exploits the fact that oligonucleotide distributions in the coding regions are different from those for the noncoding regions.

False

True

Question 7 of 10

Question 8 of 10

8. In Property-based measures, displaying physical properties on the molecular surface of molecules can help to guide molecular docking.

True

False

Question 8 of 10

Question 9 of 10

9. The advantage of the ab initio method is that the sequence can be applied as such without having to obtain experimental information.

False

True

Question 9 of 10

Question 10 of 10

10. Which of the following is untrue about translation and transcription?

The first is capping is at the 5’ end of the transcript which involves methylation at the initial residue of the RNA

The splicing process involves a large RNA-protein complex called spliceosome

The second event is splicing, which is the process of removing introns and joining exons

The second event is splicing, which is the process of removing exons and joining introns

Question 10 of 10