Bioinformatics Practice Test 10

1. Which of the given statements is incorrect about All-against-all Self-comparison?

In all-against-all proteome comparison, the similar sequences are ranked by the quality and length of the alignments found

In all-against-all proteome comparison, each protein is used as a query in a similarity search against the remaining proteome

A comparison of each protein in the proteome with all other proteins distinguishes unique proteins from proteins that have arisen from gene duplication, and also reveals the number of protein families but the domain content of these proteins cannot be known

In all-against-all proteome comparison, The search is conducted with each alignment score receiving a statistical evaluation (P or E value)

2. The ultimate step in genome analysis is to collect the information found on gene and protein sequences, alignments, gene function and location, protein families and domains, relationships of genes to those in other organisms, chromosomal rearrangements, and so on, into a comprehensive database.

True

False

3. New gene functions are thought to be gained by duplication of an existing gene creating two tandem copies.

True

False

4. In nondividing cells, a mixture of lightly and darkly stained chromosomal regions called euchromatin and heterochromatin respectively, are observed.

False

True

5. Which of the given statements is incorrect about Clustering by single linkage?

This procedure and the algorithms are the same as those used to make a phylogenetic tree by the distance methods

In First step, a group of related sequences found in the all-against-all proteome comparison is subjected to a multiple sequence alignment usually by CLUSTALW

A distance matrix that shows the number of amino acid changes between each pair of sequences is made

A neighbor-joining algorithm is rarely used in this method

6. A third category of TEs has features of both class I and class II TEs. These miniature, inverted repeat TEs (MITES) are ________ in length.

300 kbp

600 kbp

500 Mbp

400 bp

7. _____ of the human genome comprises one particular family of the SINE Element, designated Alu (1.2 million copies).

20%

10%

40%

60%

8. More than _____ of the human genome consists of interspersed repetitive sequences derived from TEs (transposable elements).

half

one-eighth

one-third

one-fifth

9. A genome database may also be interfaced with other types of data, such as clinical data.

True

False

10. Which of the given statement is incorrect?

In a given organism or species, genes are found in a given order that is maintained on the chromosomes from one generation to the next

Clustering of related genes presumably provides an evolutionary advantage to a species

Genes with a related function are frequently found to be distorted on a chromosome

A possibility is that there is genetic variation (alleles) within each gene in a cluster of a given species and that only certain allelic combinations of different genes are compatible