Drug and Pharmaceutical Biotechnology Practice Test 4

1. In plasma drug concentration versus time graph as shown in the picture, what should be the correct option for the marked place?

Maximum safe concentration

Therapeutic range

Minimum effective concentration

Onset time

2. Which of the following is not a category of 2 compartment model?

Two compartment model with elimination from the central compartment

Two compartment model with elimination from both the compartments

Two compartment model with elimination from the peripheral compartment

Two compartment model with elimination from only plasma and blood

3. What is the equation to find out hepatic clearance?

Rate of elimination by kidney/plasma drug concentration

1 / plasma drug concentration

1 / rate of elimination by the kidney

Plasma drug concentration/rate of elimination by the kidney

4. Which of the following compounds are used as agents to determine Glomerular Filtration Rate?

Calcium ion

Calcium carbonate

Albumin

Creatinine

5. Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.

False

True

6. What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

148.80ml²/ng min

150ml²/ng min

140ml²/ng min

152ml²/ng min

7. What is the molecular weight cut off for biliary excretion?

Less than 300 Dalton

More than 300 Dalton

More than 200 Dalton

Less than 200 Dalton

8. What is the equation to find out the apparent volume of distribution?

Plasma drug concentration/amount of drug in the body

Amount of drug in the body/plasma drug concentration

1 / plasma drug concentration

1 / Amount of drug in the body

9. A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.

80 ml/min

90 ml/min

85 ml/min

96.25 ml/min

10. In which of the model peripheral compartments are connected to a central compartment?

Caternary model

Mammillary model

Compartment model

Physiologic model