Drug and Pharmaceutical Biotechnology Practice Test 1

1. In the equation, Wo1/3-W1/3=Kt, K stands for ____________

Dissolution constant

The original mass of the drug

Mass of the drug remaining after time t

Concentration of solute

2. What does the interfacial barrier model states?

Turbulence in the dissolution medium exists at the solid/liquid interface

Formation a thin film or layer at the solid-liquid interface

Solutes passes easily through the interfaces

An intermediate concentration exists at the interface

3. Which of the following equations correct for Henderson-Hasselbach equation for weak bases?

PH = pKa + log (Unionized drug concentration /Ionized drug concentration)

PH = pKa + log (Ionized drug concentration/ Unionized drug concentration)

PH = pKa - log (Ionized drug concentration/ Unionized drug concentration)

PH = pKa - log (Unionized drug concentration /Ionized drug concentration)

4. Which theory takes into account that a thin film is created by the solution of the solid at the solid-liquid interface?

Interfacial barrier model

Diffusion layer model

Danckwert’s model

Penetration or surface renewal theory

5. According to the pH-partition hypothesis which one of the given options doesn't govern the absorption?

Lipid solubility of unionized drugs

PH at the absorption site

The molecular size of the drug

Dissociation constant

6. What is the driving force of Pore Transport?

Hydrostatic pressure

Electrochemical gradient

Concertation Gradient

Charge equilibration

7. A drug can be absorbed by more than one mechanism.

True

False

8. Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?

Non polar head

Hydrophobic head

Hydrophobic core

Polar head

9. Which kind of absorption mechanism is showing in the following picture?

Endocytosis

Facilitated diffusion

Passive transport

Active transport

10. Ibuprofen a weak acid, in the stomach will be present in which of the given form?

Will form aggregate

Ionized form mostly

Non-ionized form mostly

Half ionized and half no ionized