Drug Absorption Test – 3

1. Example of a drug which has PKa > 11 is ________

2. What should be the range of oil/water partition coefficient of any drug?

3. Which one of these is an example of a strong acid drug?

4. According to the pH-partition hypothesis which one of the given options doesn't govern the absorption?

5. Which of the following equations correct for Henderson-Hasselbach equation for weak bases?

6. All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.

7. Heroin with pKa 7.8 will be in which form in intestinal pH?

8. Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

9. Which one of these is not an example of a basic drug with pKa range 5-11?

10. Nitrazepam a weak base, will be in which form in the stomach?

11. Ibuprofen a weak acid, in the stomach will be present in which of the given form?

12. Which of the following equations correct for Henderson-Hasselbach equation for weak acids?

13. What is the pH range of the stomach?

14. What is the pH range of the intestine?

15. If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.